NVP-BGJ398 (INFIGRATINIB)

Background Information:

NVP-BGJ398 is a potent, selective and orally active pan-FGFR
inhibitor, with IC50s of 0.9, 1.4, 1.0 and 60 nM for FGFR1, 2, 3 and 4,
respectively.

Reference:

1. Vito Guagnano, et al, Discovery of
3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea
(NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth
Factor Receptor Family of Receptor Tyrosine Kinase, J. Med. Chem.,
2011, 54 (20), pp 7066–7083.

APIM050208: NVP-BGJ398 (INFIGRATINIB)

CAS No.: 872511-34-7.
Molecular Formula: C₂₆H₃₁Cl₂N₇O_3.
Molecular Weight: 560.49.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.