NVP-BEZ235

Background Information:

An Orally active dual inhibitor of the Phosphatidylinositol-3-kinase
(PI3K) and the downstream mammalian target of rapamycin (mTOR),
displaying potent in vivo antitumor activity.

Reference:

1. Maira, SM., et al. Identification and characterization of
NVP-BEZ235, a new orally available dual phosphatidylinositol
3-kinase/mammalian target of rapamycin inhibitor with potent in vivo
antitumor activity. Mol Cancer Ther, 2008, 7(7), 1851–1863.
2. J. A. Engelman, et al, Effective use of PI3K and MEK inhibitors to
treat mutant Kras G12D and PIK3CA H1047R murine lung cancers, Nature
Medicine, 14, 1351-1356 (2008)*Our product NVP-BEZ235 is readily soluble
at ROOM TEMPERATURE in N-methyl-2-pyrrolidone (NMP), and DMSO at a
concentration at least 10mg/ml.

APIM050207: NVP-BEZ235

CAS No.: 915019-65-7.
Molecular Formula: C₃₀H₂₃N₅O.
Molecular Weight: 469.55.
Purity: 99% (HPLC at 214 and 254 nm).
QC: ¹HNMR, HPLC and MS.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.