Background Information:

MK-5108 (VX-689) is a potent, selective and ATP competitive inhibitor
of Aurora A with IC50 < 1 nM, highly selective (220- and 190-fold)
against Aurora B and C, respectively. It is currently in clinical
evaluations.

Reference:

1. T Shimomura, et al. MK-5108, a highly selective Aurora-A kinase
inhibitor, shows antitumor activity alone and in combination with
docetaxel. Mol. Cancer Ther. 2010, 9(1), 157-166.

APIM050201: MK-5108

CAS No.: 1010085-13-8.
Molecular Formula: C₂₂H₂₁ClFN₃O₃S ? 1.9HCl.
Molecular Weight: 531.2.
Purity: 99.5% Purity (HPLC, detected at 214, 254 and 280 nm).
QC: HPLC, ¹HNMR and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.