LHC-165

Background Information:

LHC-165 is an agonist (activator) of Toll-like Receptor 7 (TLR7), and
an immuno-oncology modulator. TLR7 is a protein in the immune system
that surveys and recognizes pathological malignance, and triggers the
immune response by releasing infection-clearing cytokines if activated.
It has demonstrated in mice that LHC-165 induced immune response, and
reduced tumor growth, also showed signs of an abscopal effect. It is
currently under evaluation in patients with advanced malignancies,
either as a single agent or in combination with checkpoint inhibitor.

APIM050038: LHC-165

CAS No.: 1258595-14-0.
Molecular Formula: C₂₉H₃₂F₂N₃O₇P.
Molecular Weight: 603.6 (refer to the Certificate of Analysis, batch-specific).
Purity: >99.5% Pure by HPLC.
QC: HPLC, MS, NMR, and Quantitative Elemental analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.