Catalog No.	A22350
Product Name	[KO Validated] PMS2 Rabbit mAb (A22350)
Supplier Name	ABclonal, Inc.
Brand Name	Abclonal
Synonyms	MLH4; PMS-2; PMSL2; HNPCC4; LYNCH4; MMRCS4; PMS2CL
Gene Name	PMS2
Protein Name	PMS2
Uniprot/Swissprot ID	P54278
Gene ID	5395
Clone	ARC2479
Clonality	Monoclonal
Source/Host	Rabbit
Reactivity	Human
Conjugate	Unconjugated
Note	Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline	Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

A22350: [KO Validated] PMS2 Rabbit mAb

The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.

Immunogen Information about [KO Validated] PMS2 Rabbit mAb (A22350)

Immunogen：Recombinant protein of human PMS2.
Sequence：service@abclonal.com
Gene ID：5395
Swiss prot：P54278
Synonyms：MLH4; PMS-2; PMSL2; HNPCC4; LYNCH4; MMRCS4; PMS2CL; S2
Calculated MW：96kDa
Observed MW：110kDa

Images of [KO Validated] PMS2 Rabbit mAb (A22350)

Western blot analysis of lysates from Jurkat cells, using [KO Validated] PMS2 Rabbit mAb (A22350) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.

Western blot analysis of lysates from wild type (WT) and PMS2 knockout (KO) HeLa cells, using [KO Validated] PMS2 Rabbit mAb (A22350) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.

Please remember our product information: [KO Validated] PMS2 Rabbit mAb (Catalog Number: A22350) Abclonal

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