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Human PD-1/PDCD1 Protein (PD1-HM301)

Human PD-1/PDCD1 Protein (PD1-HM301)

Human PD-1/PDCD1 Protein (PD1-HM301)

$135.00$450.00

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$135.00$450.00

KACTUS Biosystems Human PD-1/PDCD1 Protein (PD1-HM301) (catalog No. PD1-HM301) is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Leu25-Gln167.

SKU: PD1-HM301
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Catalog No. PD1-HM301
Product NameHuman PD-1/PDCD1 Protein (PD1-HM301)
Supplier Name KACTUS Biosystems
Brand Name KACTUS Biosystems
Synonyms PDCD1; PD1; CD279; SLEB2; PD-1
Species Human
Source HEK293
Accession Q15116-1
Product Tag C-mFc
Biotinylated no
Exact Sequence Leu25-Gln167
Molecular Weight The protein has a predicted MW of 41.6 kDa. Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result.
Activity Immobilized Human PD-1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Human PD-L1, hFc Tag with the EC50 of 0.93ug/ml determined by ELISA (QC Test). See testing image for detail.
Form Lyophilized
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per μg by the LAL method.
Shipping Shipped at ambient temperature.
Stability & Storage '-20 to -80°C for 12 months as supplied from date of receipt.; -20 to -80°C for 3-6 months in unopened state after reconstitution.; 2-8°C for 2-7 days after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Note Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

PD1-HM301: Human PD-1/PDCD1 Protein (PD1-HM301)

Recombinant Human PD-1/PDCD1 Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Leu25-Gln167.

Programmed Death-1 receptor (PD-1), also known as CD279, is type I transmembrane protein belonging to the CD28 family of immune regulatory receptors.PD1 is a inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation.

Please remember our product information: Human PD-1/PDCD1 Protein (PD1-HM301) catalog number: PD1-HM301 KACTUS Biosystems

Additional information

Ship from Country

USA

Size

100 ug, 500 ug

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