Human IgG4-S228P Bispecific Isotype Control Antibody (4F17 / HEL D1.3.) | PA008011.h4
$595.00 – $1,750.00
Recombinant human IgG4-S228P bispecific isotype control antibodies good for in vitro and in vivo studies. Low or no specific binding to human, mouse, and rat samples tested.
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| Catalog No. | PA008011.h4 |
|---|---|
| Product Name | Human IgG4-S228P Bispecific Isotype Control Antibody (4F17 / HEL D1.3.) | PA008011.h4 |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | hIgG4 Isotype Control, Human IgG4 Isotype Control, hIgG4 S228P, hIgG4 SPLEPG Mutant |
| Clone | 4F17 / HEL D1.3. |
| Isotype | human IgG4, kappa. |
| Applications | an isotype-matched negative control for human IgG4-S228P kappa bispecific antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research. |
| Form Of Antibody | 0.2 μM filtered solution of 1x PBS. |
| Endotoxin | Less than 1 EU/mg of protein as determined by LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions. |
| Shipping | The In Vivo Grade Recombinant Human IgG4-S228P Bispecific Isotype Control Antibody are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 3 month from date of receipt, 2 to 8°C as supplied. 12 months from date of receipt, -20°C to -70°C as supplied. |
| Note | Recombinant human IgG4-S228P bispecific isotype control antibodies good for in vitro and in vivo studies. Low or no specific binding to human, mouse, and rat samples tested. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA008011.h4: In Vivo Grade Recombinant Human IgG4-S228P Bispecific Isotype Control Antibody
The in vivo grade recombinant human IgG4-S228P bispecific antibody was produced in mammalian cells.
Background
The ideal recombinant human IgG4 bispecific isotype control antibody (hIgG4 S228P kappa bispecific isotype control) has low or no specific binding to any human sample, and humanized or completely human variable regions in addition to the human IgG4 S228P kappa constant regions. The human IgG4 kappa bispecific isotype control and mutants can be used in the cell-based assay or animal model as the antibody negative control when evaluating fully human, humanized, or chimeric antibodies.
The hIgG4 bispecific isotype control mutants were generated because the corresponding mutations had been introduced to some human IgG4 therapeutic antibody candidates. For example, S228P, an engineered mutation in the core hinge region, is used to prevent Fab-arm exchange in vivo of human IgG4 molecules; P329G substitution combined with S228P and L235E was shown to decrease effector functions by disrupting the Fc/Fcγ receptor interface. When clients test their engineered antibody candidates, the silent Fc effctor function human IgG4 isotype controls are useful for in vivo use.
Welcome to contact us and ask for a quote for the engineered human IgG4 bispecific isotype control mutants, hIgG4 bispecific isotype control and Fc silenced mutants with Avi-, His-, and Flag-tags, and biotinylated hIgG4 bispecific isotype control and silent Fc mutants. A variety of conjugates (such as dyes and fluorophores) with the human IgG4 bispecific isotype control and silent Fc effctor function mutants are available.
Recombinant anti-HEL / HEL Bispecific Isotype Control Antibodies:
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG1 Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2a Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2c Kappa Bispecific Isotype Control Antibody
Recombinant human IgG Bispecific Isotype Control Antibodies:
In vivo Grade Recombinant Human IgG1 Bispecific Isotype Control Antibody
In vivo Grade Recombinant Human IgG4 Bispecific Isotype Control Antibody
Other Recombinant IgG Reference Antibodies:
In vivo Grade Recombinant Human IgG1 Isotype Control Antibody and Mutants
In vivo Grade Recombinant Human IgG2 Isotype Control Antibody
In vivo Grade Recombinant Human IgG3 Isotype Control Antibody
In vivo Grade Recombinant Human IgG4-S228P Isotype Control Antibody and Mutants
In vivo Grade Recombinant Mouse IgG1 Isotype Control Antibody and Mutants
In vivo Grade Recombinant Mouse IgG2a Isotype Control Antibody and Mutants
In vivo Grade Recombinant Mouse IgG2b Isotype Control Antibody and Mutants
In vivo Grade Recombinant Mouse IgG2c Isotype Control Antibody and Mutants
In vivo Grade Recombinant Mouse IgG3 Isotype Control Antibody
In vivo Grade Recombinant Rat IgG1 Isotype Control Antibody
In vivo Grade Recombinant Rat IgG2a Isotype Control Antibody
In vivo Grade Recombinant Rat IgG2b Isotype Control Antibody
In vivo Grade Recombinant Rat IgG2c Isotype Control Antibody
In Vivo Grade Recombinant Human IgG4-S228P Bispecific Isotype Control Antibody from: In Vivo Grade Recombinant Human IgG4-S228P Bispecific Isotype Control Antibody: PA008011.h4 Syd Labs
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