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Human ALK-1/ACVRL1 Protein (ALK-HM101)
$216.00 – $720.00
KACTUS Biosystems Human ALK-1/ACVRL1 Protein (ALK-HM101) (catalog No. ALK-HM101) is expressed from HEK293 with His tag at the C-Terminus.It contains Asp22-Gln118.
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| Catalog No. | ALK-HM101 |
|---|---|
| Product Name | Human ALK-1/ACVRL1 Protein (ALK-HM101) |
| Supplier Name | KACTUS Biosystems |
| Brand Name | KACTUS Biosystems |
| Synonyms | ACVRLK1; ORW2; ALK1; ALK-1; EC 2.7.11; HHT; HHT2; SKR3; TSR-I; ACVRL1 |
| Species | Human |
| Source | HEK293 |
| Accession | P37023 |
| Product Tag | C-His |
| Biotinylated | no |
| Exact Sequence | Asp22-Gln118 |
| Molecular Weight | The protein has a predicted MW of 11.5 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per μg by the LAL method. |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | '-20 to -80°C for 12 months as supplied from date of receipt.；-20 to -80°C for 3-6 months in unopened state after reconstitution.；2-8°C for 2-7 days after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
ALK-HM101: Human ALK-1/ACVRL1 Protein (ALK-HM101)
Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 is not an inhibitor of BMP9, which is confirmed by experimental evidence.
Please remember our product information: Human ALK-1/ACVRL1 Protein (ALK-HM101) catalog number: ALK-HM101 KACTUS Biosystems
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