HER2/ErbB2 Rabbit mAb (A21248)
$148.00 – $548.00
Abclonal HER2/ErbB2 Rabbit mAb (Catalog Number: A21248) encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors.
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| Catalog No. | A21248 |
|---|---|
| Product Name | HER2/ErbB2 Rabbit mAb (A21248) |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2) |
| Gene Name | ERBB2 |
| Protein Name | ERBB2 |
| Uniprot/Swissprot ID | P04626 |
| Gene ID | 2064 |
| Clone | ARC5120-02 |
| Clonality | Monoclonal |
| Source/Host | Rabbit |
| Reactivity | Human |
| Conjugate | Unconjugated |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
A21248: HER2/ErbB2 Rabbit mAb
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Immunogen Information about HER2/ErbB2 Rabbit mAb (A21248)
Immunogen：Recombinant protein of human HER2/ErbB2.
Gene ID：2064
Swiss prot：P04626
Synonyms：NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2); HER2/ErbB2
Calculated MW：138kDa
Observed MW：185kDa
Images of HER2/ErbB2 Rabbit mAb (A21248)
Western blot analysis of extracts of SK-BR-3 cells, using HER2/ErbB2 antibody (A21248) at1:2000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 1s.
Immunohistochemistry analysis of HER2/ErbB2 in paraffin-embedded Human breast cancer using HER2/ErbB2 antibody (A21248) at dilution of 1:200(40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please remember our product information: HER2/ErbB2 Rabbit mAb (Catalog Number: A21248) Abclonal
