GS-4997 (SELONSERTIB)

Background Information:

GS-4997 (Selonsertib), a clinical stage, orally bioavailable small
molecule, is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1)
with potential anti-inflammatory, antineoplastic and anti-fibrotic
activities. GS-4997 targets and binds to the catalytic kinase domain of
ASK1 in an ATP-competitive manner, thereby preventing its
phosphorylation and activation. GS-4997 prevents the production of
inflammatory cytokines, down-regulates the expression of genes involved
in fibrosis, suppresses excessive apoptosis and inhibits cellular
proliferation.

APIM050158: GS-4997 (SELONSERTIB)

CAS No.: 1448428-04-3.
Molecular Formula: C24H24FN7O.
Molecular Weight: 445.5 (or refer to Certificate of Analysis, batch-specific).
Purity: 99.5% by achiral HPLC, Lot 01.
QC: HPLC-MS, 1H-NMR and Quantitative Elemental Analysis.
Solubility: Refer to Certificate of Anlysis.
Storage: Refer to Certificate of Anlysis.