CGAMP, SODIUM SALT

2′,3′-cGAMP (cyclic [G(2’,5’)pA(3’,5’)p]) is the endogenous agonist for the STING (STimulator of INterferon Genes), a receptor crucial to activate the innate immune system. It is a noncanonical cyclic dinucleotide (CDN) produced as a second messenger in mammalian cells by the cytosolic cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. The binding potency of noncanonical 2′,3′-cGAMP for human STING is much better than that of the canonical 3′,3′-cyclic dinucleotides (CDNs) produced in bacterial, with a Kd of 4.6 nM compared to >1 μM for bacterial 3′,3′-CDNs (refs 1-3).

Reference:

1. Zhang X. et al., 2013. Cyclic GMP-AMP containing mixed phosphdiester linkages is an endogenous high-affinity ligand for STING. Mol Cell.51(2):226-35.
2. Diner E. et al., 2013. The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING. Cell Rep. 3(5):1355-61.
3. Gao P. et al., 2013. Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 153(5):1094-107.

APIM050001: CGAMP, SODIUM SALT

CAS No.: 1441190-66-4.
Molecular Formula: C20H22N10O13P2 ·2Na.
Molecular Weight: 718.4. About 1 mg powder equals to 1.39 µmol.
Purity: >99.5% by HPLC, snow-white, disodium salt. in vivo grade material.
QC: HPLC, MS, 1H-, 31P- NMRs.
Solubility: Water, >50 mM.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.