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Description
Background Information:
Birinapant (TL32711) is a cell permeable, orally bioavailable, synthetic bivalent small molecule peptido mimetics of second mitochondrial-derived activator of caspases (SMAC) and potent and selective inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with Kd values of 45 nM and <1 nM for XIAP and cIAP1, respectively. SMAC mimetics Birinapant and LCL-161 (our Prod No CT-LCL-161) are also negative regulators of HIV-1 transcription, promoting reversal of viral latency (Ref. 3).
Reference:
1. C. A. Benetatos, et al., Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft Models, Mol Cancer Ther, April 2014, 13; 867.
2. C. Krepler, et al., The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells. Clin Cancer Res. 2013 Apr 1;19(7):1784-94.
3. L. Pache, et al, BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency. Cell Host Microbe. 2015 Sep 9;18(3):345-53. doi: 10.1016/j.chom.2015.08.009.
APIM050295: BIRINAPANT
CAS No.: 1260251-31-7.
Molecular Formula: C42H56F2N8O6? 2 HCl.
Molecular Weight: 879.9.
Purity: 99.5% by HPLC.
QC: HPLC-MS, 1HNMR, Chiral HPLC and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
Additional information
| Ship from Country | USA |
|---|---|
| Size | 10 mg |
