Anti-mouse TCR beta Antibody (Clone: H57-597) | PA007520.m2a
$150.00 – $900.00
Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
- Details & Specifications
- References
| Catalog No. | PA007520.m2a |
|---|---|
| Name | Anti-mouse TCR beta Antibody (Clone: H57-597) | PA007520.m2a |
| Product Name | In Vivo Grade Recombinant Anti-mouse TCR beta Monoclonal Antibody (Clone: H57-597), Mouse IgG2a Lambda |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | Tib; TCRbeta |
| Clone | H57-597. |
| Isotype | Mouse IgG2a Lambda. |
| Source/Host | The anti-mouse TCRβ monoclonal antibody (clone: H57-597) was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade recombinant mouse monoclonal antibody (clone: H57-597) specifically binds to the mouse TCRβ. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TCRβ protein. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA007520.m2a: In Vivo Grade Recombinant Anti-mouse TCRβ Monoclonal Antibody (Clone: H57-597), Mouse IgG2a Lambda
Recombinant Mouse IgG2a Monoclonal Antibody.
References of Anti-Mouse TCR beta Monoclonal Antibody (Clone: H57-597)
1. Transient Anti-TCRβ mAb Treatment Induces CD4+ T Cell Exhaustion and Prolongs Survival in a Mouse Model of Systemic Lupus Erythematosus.
Gonzalez, N. M., et al. Immunology. 2025 Feb;174(2):239-246. doi: 10.1111/imm.13881. PMID: 39648274
“Here, we investigated the therapeutic potential of the anti-TCRβ (anti-mouse TCR beta H57-597) monoclonal antibody (anti-mouse TCR beta H57-597 mAb) (mAb) in a mouse model of SLE. …Chronic T cell receptor (TCR) signalling induces T cell exhaustion, characterised by reduced capacity to induce tissue damage. …T cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). …Subsequently, mouse survival was monitored daily. …Accordingly, MRL/lpr mice in the anti-TCRβ mAb group exhibited decreased proteinuria scores and minimal renal pathological damage compared to the PBS control group…”
2. Anti-TCRβ mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice.
Ronghai Deng, et al. Transplantation. 2014 Jun 27;97(12):1216-24. doi: 10.1097/TP.0000000000000120. PMID: 24854475
“T-cell response to islet allografts was potently abrogated by a brief treatment with an anti-TCRβ mAb (clone H57-597), resulting in long-term survival of BALB/c islet allografts in streptozotocin-induced diabetic B6 mice…”
3. Anti-TCRβ mAb in Combination With Neurogenin3 Gene Therapy Reverses Established Overt Type 1 Diabetes in Female NOD Mice.
Aini Xie, et al. Endocrinology. 2017 Oct 1;158(10):3140-3151. doi: 10.1210/en.2016-1947. PMID: 28977608
“These diabetic NOD mice were transiently treated with an anti-TCRβ chain (TCRβ) mAb, H57-597, for 5 days. Two weeks later, some NOD mice with established overt diabetes further received hepatic gene therapy using the islet-lineage determining gene Neurogenin3 (Ngn3), in combination with the islet growth factor gene betacellulin (Btc)…”
Syd Labs provides the following recombinant anti-mouse TCRβ monoclonal antibodies for flow cytometry:
Recombinant Anti-mouse TCRβ monoclonal antibody (Clone: H57-597) for flow cytometry
In Vivo Grade Recombinant Anti-mouse TCR beta Monoclonal Antibody (Clone: H57-597), Mouse IgG2a Lambda from: In Vivo Grade Recombinant Anti-mouse TCR beta Monoclonal Antibody (Clone: H57-597), Mouse IgG2a Lambda: PA007520.m2a Syd Labs
You may also like…
- Select optionsQuick View
- Select optionsQuick View