Catalog No.	PA008014.m2cLA
Product Name	Anti-mouse PD-1 / VEGF-A Bispecific Antibody (Clone:RMP1-14.1/B20-4.1.1.1) | PA008014.m2cLA
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	PD-1 / VEGF Bispecific, PD1 / VEGF-A Bispecific, VEGF / PD-1 Bispecific, VEGF-A / PD-1 Bispecific
Clone	RMP1-14.1, the same variable region sequences as the rat anti-mouse PD-1 monoclonal antibody (clone number: RMP1-14). B20-4.1.1.1, the same variable region sequences as the mouse anti-mouse VEGF monoclonal antibody (clone number: B20-4.1.1).
Isotype	mouse IgG2c, kappa.
Applications	immunohistochemistry (IHC), Flow Cytometry (FC), and various in vitro and in vivo functional assays.
Form Of Antibody	0.2 μM filtered solution of 1x PBS.
Endotoxin	Less than 1 EU/mg of protein as determined by LAL method.
Purity	>95% by SDS-PAGE under reducing conditions.
Shipping	The in vivo grade recombinant rat anti-mouse PD-1 / VEGF-A bispecific antibodies are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 3 month from date of receipt, 2 to 8°C as supplied. 12 months from date of receipt, -20°C to -70°C as supplied.
Note	Recombinant anti-mouse PD-1 / VEGF bispecific antibodies share the variable region sequences with the rat anti-mouse PD-1 antibody (clone number: RMP1-14) and the mouse anti-mouse VEGF antibody (clone number: B20-4.1.1). The recombinant mouse IgG2c LALAPG bispecific isotype control antibody available.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA008014.m2cLA: In Vivo Grade Recombinant Anti-mouse PD-1 / VEGF-A Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / B20-4.1.1.1)

The in vivo grade recombinant anti-mouse PD-1 / VEGF-A bispecific antibody (mouse IgG2c LALAPG Kappa) was produced in mammalian cells.

Background

The rat anti-mouse PD-1 monoclonal antibody (clone No. RMP1-14, rat IgG2a kappa) reacts with the mouse PD-1 protein (CD279 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The RMP1-14 antibody blocks the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein.

It is under investigation how the recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies (RMP1-14.1 / B20-4.1.1.1) behave different from the individual monoclonal antibodies and their combination.

Our recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: RMP1-14) and the mouse anti-mouse VEGF-A antibody (hybridoma clone name or number: B20-4.1.1).

Recombinant anti-HEL / HEL Bispecific Isotype Control Antibodies:
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG1 Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2a Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2c Kappa Bispecific Isotype Control Antibody
Syd Labs provides the following anti-mouse PD1 (PD-L1) and VEGFA monoclonal antibodies:
In vivo grade recombinant anti-mouse PD-1 monoclonal antibodies (Clone RMP1-14.1)
In vivo grade recombinant anti-mouse PD 1 monoclonal antibodies (Clone 29F.1A12.1)
In vivo grade recombinant anti-mouse PD-L1 monoclonal antibodies (Clone 10F.9G2.1)
In vivo grade recombinant anti-mouse VEGFA monoclonal antibodies (Clone B20-4.1.1.1))
In vivo grade recombinant anti-mouse VEGF-A monoclonal antibodies (Clone G6-31)
In vivo grade recombinant anti-mouse VEGF monoclonal antibodies (Clone G6-23)
Syd Labs provides the following anti-mouse PD-1 / VEGFA bispecific antibodies:
In vivo grade recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies (Clone RMP1-14.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD1 / VEGFA bispecific antibodies (Clone 29F.1A12.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD-1 / VEGF bispecific antibodies (Clone RMP1-14.1 / G6-23)
In vivo grade recombinant anti-mouse PD1 / VEGF bispecific antibodies (Clone 29F.1A12.1 / G6-23)
In vivo grade recombinant anti-mouse PD 1 / VEGF bispecific antibodies (Clone RMP1-14.1 / G6-31)
In vivo grade recombinant anti-mouse PD-1 / VEGF A bispecific antibodies (Clone 29F.1A12.1 / G6-31)
Syd Labs provides the following anti-mouse PD-L1 / VEGFA bispecific antibodies:
In vivo grade recombinant anti-mouse PD-L1 / VEGF-A bispecific antibodies (Clone 10F.9G2.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD-L1 / VEGF bispecific antibodies (Clone 10F.9G2.1 / G6-23)
In vivo grade recombinant anti-mouse PDL1 / VEGF bispecific antibodies (Clone 10F.9G2.1 / G6-31)

In Vivo Grade Recombinant Anti-mouse PD-1 / VEGF-A Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / B20-4.1.1.1) from: In Vivo Grade Recombinant Anti-mouse PD-1 / VEGF-A Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / B20-4.1.1.1): PA008014.m2cLA

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