Anti-mouse IL-2 Antibody (Clone:S4B6-1) | PA007555.r2a
$150.00 – $900.00
Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
- Details & Specifications
- References
| Catalog No. | PA007555.r2a |
|---|---|
| Product Name | In Vivo Grade Recombinant Anti-mouse IL-2 Monoclonal Antibody (Clone: S4B6-1), Rat IgG2a Kappa |
| Data Sheet | 📄 Download Product Data Sheet (PDF) |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | il 2, Interleukin, interleukin 2 |
| Clone | S4B6-1. |
| Isotype | Rat IgG2a kappa. |
| Source/Host | The anti-mouse IL-2 monoclonal antibody (clone: S4B6-1) was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade recombinant rat monoclonal antibody (clone: S4B6-1) specifically binds to mouse IL-2. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse IL-2 protein. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The in vivo grade recombinant anti-mouse IL-2 monoclonal antibody of clone S4B6-1 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA007555.r2a: In Vivo Grade Recombinant Anti-mouse IL-2 Monoclonal Antibody (Clone: S4B6-1), Rat IgG2a Kappa
Recombinant rat IgG2a Monoclonal Antibody.
References of Anti-Mouse IL-2 Monoclonal Antibody (Clone: S4B6-1)
1. Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection.
Littwitz-Salomon, E., et al.Retrovirology. 2015 Jul 30;12:66. doi: 10.1186/s12977-015-0191-3. PMID: 26220086
“Suppression of NK cell functions depended on IL-2 consumption by Tregs, which could be overcome by specific NK cell stimulation with an IL-2/anti-IL-2 mAb complex. … Suppression by Tregs, which was mediated by IL-2 consumption, led to increased viral loads and reduced cytotoxicity of NK cells in vivo. … To confirm that IL-2 is an important factor in Treg-mediated suppression of NK cell responses, we specifically stimulated NK cells with IL-2 using a complex of anti-mouse IL-2 mAb (clone S4B6-1) in combination with recombinant mouse IL-2 protein. … Here, we describe a new suppressive mechanism of Tregs on NK cell functions during an acute viral infection that is dependent on IL-2 availability or IL-2 consumption by Tregs. … If indicated, Tregs were depleted by repeated injections of DT and mice were stimulated by injections of IL-2/anti-IL-2 mAb complex.”
For more technical references or data sheets regarding the Recombinant Anti-Mouse IL-2 Monoclonal Antibody (Clone: S4B6-1) formats, please contact our scientific support team at message@sydlabs.com.
In Vivo Grade Recombinant Anti-mouse IL-2 Monoclonal Antibody (Clone: S4B6-1), Rat IgG2a Kappa from: In Vivo Grade Recombinant Anti-mouse IL-2 Monoclonal Antibody (Clone: S4B6-1), Rat IgG2a Kappa: PA007555.r2a
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