Catalog No.	PA007501.m2b
Product Name	Anti-mouse CTLA-4 Antibody for Flow Cytometry | PA007501.m2b
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	cytotoxic T-lymphocyte associated antigen 4, cytotoxic T-lymphocyte antigen 4, CD152, CTLA4
Clone	9D9.
Isotype	Mouse IgG2b Kappa.
Source/Host	The anti-mouse CTLA-4 monoclonal antibody (clone: 9D9) for Flow Cytometry was produced in mammalian cells.
Specificity/Sensitivity	The recombinant 9D9 antibody for Flow Cytometry specifically binds to mouse CTLA-4 protein.
Applications	Flow cytometry (FC), and Immunohistochemistry - Frozen (IHC-F).
Form Of Antibody	0.2 uM filtered solution, pH 7.4, containing 0.09% sodium azide.
Conjugate	Non-conjugated.
Purity	>95% by SDS-PAGE under reducing conditions.
Shipping	The Recombinant Anti-mouse CTLA-4 Monoclonal Antibody (Clone: 9D9) for Flow Cytometry, Mouse IgG2b Kappa is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, 2 to 8°C as supplied. Do not freeze it.
Note	Recombinant mouse IgG2b isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007501.m2b: Recombinant Anti-mouse CTLA-4 Monoclonal Antibody (Clone: 9D9) for Flow Cytometry, Mouse IgG2b Kappa

CTLA-4, a 33-kilodalton immunoglobulin (Ig) superfamily protein, shares significant structural, genomic, and amino acid sequence similarities with CD28. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an inhibitory molecule that competes with the stimulatory CD28 for binding to B7 on antigen presenting cells. CTLA-4 and CD28 are both presented on the surface of T-cells. Functioning as a critical immune checkpoint receptor, CTLA-4 plays a central role in downregulating immune responses to maintain homeostasis. It regulates protective immunity development, supports thymocyte activity, and ensures the induction and long-term maintenance of immunological tolerance. These biological properties position CTLA-4 as a dual-action therapeutic target: its agonist applications can suppress excessive immune activity in autoimmune disorders, while antagonist strategies enhance immune activation, particularly in cancer immunotherapy. This dual functionality underscores its clinical relevance in developing treatments for conditions ranging from autoimmune diseases to malignancies, making CTLA-4 a pivotal focus in modern immunotherapy research and precision medicine advancements.

This 9D9 antibody has been reported for use in flow cytometric analysis and blocks the mouse cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.

Syd Labs provides the following research grade anti-CTLA-4 antibody biosimilars:

Ipilimumab Biosimilar, research grade, anti-human CTLA-4 monoclonal antibody
Tremelimumab Biosimilar, research grade, anti-human CTLA-4 monoclonal antibody

Anti-mouse CTLA-4 Antibody (9D9) for Flow Cytometry from: Recombinant Anti-mouse CTLA-4 Monoclonal Antibody (Clone: 9D9), Mouse IgG2b Kappa: PA007501.m2b Syd Labs

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