Anti-Human / Mouse Integrin beta7 Antibody (Clone:FIB504.64) | PA007589.r2a
$150.00 – $900.00
Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
- Details & Specifications
- References
| Catalog No. | PA007589.r2a |
|---|---|
| Product Name | In Vivo Grade Recombinant Anti-human/mouse Integrin beta7 Monoclonal Antibody (Clone: FIB504.64), Rat IgG2a Kappa |
| Data Sheet | 📄 Download Product Data Sheet (PDF) |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | ITGB7, Ly69, M290 IEL |
| Clone | FIB504.64. |
| Isotype | Rat IgG2a Kappa. |
| Source/Host | The anti-human/mouse Integrin beta7 monoclonal antibody (clone: FIB504.64) was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade recombinant rat monoclonal antibody (clone: FIB504.64) specifically binds to human/mouse Integrin beta7. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human/mouse Integrin beta7 protein. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The in vivo grade recombinant anti-human/mouse Integrin beta7 monoclonal antibody of clone FIB504.64 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA007589.r2a: In Vivo Grade Recombinant Anti-human/mouse Integrin beta7 Monoclonal Antibody (Clone: FIB504.64), Rat IgG2a Kappa
Recombinant Rat IgG2a Monoclonal Antibody.
References of Anti-Human Integrin beta7 Monoclonal Antibody (Clone: FIB504.64)
1. Integrin α4β7 blockade preferentially targets systemic migration of Th1 and Th1/Th17 cells from the gut to the CNS in experimental autoimmune encephalomyelitis.
Yu, S., et al.J Neuroinflammation. 2020 Feb 4;17(1):45. doi: 10.1186/s12974-020-1698-0. PMID: 32024666
“The FIB504 antibody, reactive with mouse and human β7 integrin, blocked β7 integrin-mediated cell adhesion in a mouse model of experimental autoimmune encephalomyelitis. C57BL/6 mouse splenocytes were stained with biotinylated FIB504 and streptavidin-PE for flow cytometry, with quality control confirming binding post-oligonucleotide conjugation for TotalSeq™ conjugates.”
2. Anti-α4β7 Integrin Therapy for Inflammatory Bowel Disease: Animal Models and Clinical Data.
Li, Y., et al.Front Immunol. 2023 Mar 23;14:1140710. doi: 10.3389/fimmu.2023.1140710. PMID: 37015095
“FIB504 antibody, administered intraperitoneally, blocked α4β7 integrin in a mouse colitis model, reducing T cell infiltration into inflamed colon tissue. Mice were monitored for weight loss and histological inflammation scores, showing results comparable to vedolizumab’s clinical efficacy.”
3. Role of α4-integrins in lymphocyte homing and the pathogenesis of experimental colitis.
Hesterberg, P. E., et al.J Clin Invest. 2001 Mar;107(6):755-64. doi: 10.1172/JCI10942. PMID: 11207271
“The FIB504 monoclonal antibody, specific for β7 integrin, was injected intraperitoneally at 100 μg/mouse twice weekly in scid mice reconstituted with CD45RBhigh CD4+ T cells. This treatment significantly attenuated colonic inflammation, weight loss, mucosal hypertrophy, and leukocyte infiltration, as confirmed by histological analysis.”
For more technical references or data sheets regarding the Recombinant Anti-Human Integrin beta7 Monoclonal Antibody (Clone: FIB504.64) formats, please contact our scientific support team at message@sydlabs.com.
In Vivo Grade Recombinant Anti-human/mouse Integrin beta7 Monoclonal Antibody (Clone: FIB504.64), Rat IgG2a Kappa from: In Vivo Grade Recombinant Anti-human/mouse Integrin beta7 Monoclonal Antibody (Clone: FIB504.64), Rat IgG2a Kappa: PA007589.r2a
