Anti-Human EGFR Antibody (Clone:528) | PA007565.m2a
$150.00 – $900.00
Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
- Details & Specifications
- References
| Catalog No. | PA007565.m2a |
|---|---|
| Product Name | In Vivo Grade Recombinant Anti-human EGFR Monoclonal Antibody (Clone: 528), Mouse IgG2a Kappa |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2 |
| Clone | 528. |
| Isotype | Mouse IgG2a kappa. |
| Source/Host | The anti-human EGFR monoclonal antibody (clone: 528) was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade recombinant mouse monoclonal antibody (clone: 528) specifically binds to human EGFR. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human EGFR protein. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The in vivo grade recombinant anti-human EGFR monoclonal antibody of clone 528 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA007565.m2a: In Vivo Grade Recombinant Anti-human EGFR Monoclonal Antibody (Clone: 528), Mouse IgG2a Kappa
Recombinant mouse IgG2a Monoclonal Antibody.
References of Anti-Human EGFR Monoclonal Antibody (Clone: 528)
1. Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell lines.
Kurai, J., et al.Clin Cancer Res. 2007 Mar 1;13(5):1552-61. doi: 10.1158/1078-0432.CCR-06-1726. PMID: 17332301
“Epidermal growth factor receptor (EGFR) is commonly overexpressed in NSCLC and its overexpression frequently correlates with a poor prognosis. …There are two approaches for inhibiting EGFR signaling: to prevent ligand binding to the extracellular domain with a monoclonal antibody and to inhibit the intracellular tyrosine kinase activity with a small molecule. …These disappointing results of EGFR tyrosine kinase inhibitors have led to increased interest in the monoclonal antibodies against EGFR because these two classes of agents may have substantially different mechanisms of action. …To determine the absolute number of EGFR molecules per cell, we carried out a quantitative flow cytometric analysis using DAKO QIFIKIT (DakoCytomation, Copenhagen, Denmark) and EGFR monoclonal antibody (clone 528). …The slides were preblocked with 10% normal rabbit serum at room temperature for 20 min and incubated at 4°C overnight with the primary antibody, anti-EGFR antibody (clone 31G7).”
For more technical references or data sheets regarding the Recombinant Anti-Human EGFR Monoclonal Antibody (Clone: 528) formats, or related products from Syd Labs, please contact our scientific support team at message@sydlabs.com.
In Vivo Grade Recombinant Anti-human EGFR Monoclonal Antibody (Clone: 528), Mouse IgG2a Kappa from: In Vivo Grade Recombinant Anti-human EGFR Monoclonal Antibody (Clone: 528), Mouse IgG2a Kappa: PA007565.m2a
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