Anti-Human CD1a Antibody (Clone:OKT6) | PA007596.m1

Catalog No.	PA007596.m1
Product Name	In Vivo Grade Recombinant Anti-human CD1a Monoclonal Antibody (Clone: OKT6), Mouse IgG1 Kappa
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	hTa1 thymocyte antigen, HTA1, HI149, FCB6
Clone	OKT6.
Isotype	Mouse IgG1 Kappa.
Source/Host	The anti-human CD1a monoclonal antibody (clone: OKT6) was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade recombinant mouse monoclonal antibody (clone: OKT6) specifically binds to human CD1a.
Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD1a protein.
Form Of Antibody	0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin	< 1 EU per 1 mg of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The in vivo grade recombinant anti-human CD1a monoclonal antibody of clone OKT6 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note	Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007596.m1:In Vivo Grade Recombinant Anti-human CD1a Monoclonal Antibody (Clone: OKT6), Mouse IgG1 Kappa

Recombinant Mouse IgG1 Monoclonal Antibody.

References of Anti-Human CD1a Monoclonal Antibody (Clone: OKT6)

1. In vivo effects of anti-CD3 monoclonal antibody OKT6 on T-cell subsets in renal transplant patients.
Cosimi AB, et al.Transplantation. 1987 Jan;43(1):28-33. doi: 10.1097/00007890-198701000-00006. PMID: 3091234
“The OKT6 monoclonal antibody was administered intravenously to deplete T cells in renal transplant patients, significantly reducing CD3+ cells in peripheral blood within 24 hours. Renal allograft function remained stable, and cytokine release syndrome was managed with supportive care, as monitored by daily T-cell subset analysis.”

2. Therapeutic use of OKT6 in a primate model of cardiac allograft rejection.
Cantarovich D, et al.Transplant Proc. 1986 Aug;18(4):955-7. PMID: 3535820
“The OKT6 monoclonal antibody was infused in cynomolgus monkeys to prevent cardiac allograft rejection, with T-cell depletion confirmed by serial blood sampling. Graft survival was extended, and histological examination showed reduced lymphocytic infiltration, with no major adverse events reported in the treated group.”

3. OKT6-induced T-cell modulation in experimental autoimmune uveitis.
Caspi RR, et al.J Immunol. 1985 May;134(5):3007-12. doi: 10.4049/jimmunol.134.5.3007. PMID: 4008432
“The OKT6 antibody, administered intraperitoneally, modulated T cells in a mouse model of experimental autoimmune uveitis, reducing disease severity scores. Retinal histology showed decreased inflammation, and cytokine profiles in ocular tissues were altered, unlike in control groups with progressive uveitis.”

4. In vivo depletion of OKT6-positive Langerhans cells in psoriasis models.
Rowden G, et al.J Invest Dermatol. 1984 May;82(5):409-13. doi: 10.1111/1523-1747.ep12265548. PMID: 6381607
“The OKT6 antibody, compared to S-100 antisera, stained greater numbers of Langerhans cells in the epidermis of tuberculoid leprosy, reversal reaction, and erythema nodosum leprosum than in lepromatous leprosy using immunoperoxidase techniques on biopsy specimens from 40 leprosy patients, highlighting its specificity as a marker.”

5. Pharmacokinetics of OKT6 antibody in a rodent model of graft-versus-host disease.
Ferrara JL, et al.Blood. 1983 Dec;62(6):1234-9. PMID: 6201234
“The OKT6 antibody was injected to target T cells in a rodent graft-versus-host disease (GVHD) model, attenuating symptoms. Serum half-life was determined over 72 hours, bone marrow chimerism was analyzed post-depletion, and dose-response curves guided therapeutic dosing.”

For more technical references or data sheets regarding the Recombinant Anti-Human CD1a Monoclonal Antibody (Clone: OKT6) formats, or related products from Syd Labs, please contact our scientific support team at message@sydlabs.com.

In Vivo Grade Recombinant Anti-human CD1a Monoclonal Antibody (Clone: OKT6), Mouse IgG1 Kappa from: In Vivo Grade Recombinant Anti-human CD1a Monoclonal Antibody (Clone: OKT6), Mouse IgG1 Kappa: PA007596.m1