ZM447439

ZM447439

$140.00$450.00

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$140.00$450.00

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SKU: APIM050266
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Description

Background Information:

A potent and selective ATP-competitive inhibitor of Aurora B kinase
with an in vitro IC50 values of 50, 250 and 1000 nM for Aurora B, C and A
kinases, respectively. Selective over a range of other kinases
including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and
displays selective toxicity towards proliferating tumor cells versus
non-dividing cells.

Reference:

1. C. Ditchfield et al., J. Cell Biol., 2003, 161, 267; 2. Z. J. Long
et al., J. Cell Cycle, 2008, 7, 1473; 3. E. Walsby et al,.
Haematologica, 2008, 93, 662.

APIM050266: ZM447439

CAS No.: 331771-20-1.
Molecular Formula: C29H31N5O4 ? 3H2O.
Molecular Weight: 567.71.
Purity: >99% (HPLC).
QC: 1HNMR, HPLC.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

Additional information

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USA

Size

10 mg, 50 mg

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