VX-680

Background Information:

A small-molecule Aurora kinase inhibitor with inhibition constants
(Ki) of 0.6, 18 and 4.6 nM for Aurora kinases A, B and C, respectively;
it also inhibits Flt-3 and Abl kinases, particularly mutant forms.

Reference:

1. Cheok CF, Kua N, Kaldis P, Lane DP, et al.,Combination of nutlin-3
and VX-680 selectively targets p53 mutant cells with reversible effects
on cells expressing wild-type p53, Cell Death Differ. 2010
Sep;17(9):1486-500.
2. Donato NJ, Fang D, Sun H, et al., Targets and effectors of the
cellular response to aurora kinase inhibitor MK-0457 (VX-680) in
imatinib sensitive and resistant chronic myelogenous leukemia., Biochem
Pharmacol. 2010 Mar 1;79(5):688-97.
3. Bebbington D, Binch H, Charrier JD et al., The discovery of the
potent aurora inhibitor MK-0457 (VX-680)., Bioorg Med Chem Lett. 2009
Jul 1;19(13):3586-92.

APIM050259: VX-680

CAS No.: 639089-54-6.
Molecular Formula: C₂₃H₂₈N₈OS.
Molecular Weight: 464.6.
Purity: > 99% (HPLC).
QC: MS (EI), ¹HNMR, HPLC.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.