TAK-632

Background Information:

TAK-632 is a potent and selective pan-RAF inhibitor targeting B-RAF V600E (IC?? = 2.4 nM), C-RAF (IC?? 1.4 nM) and VEGFR (IC?? = 160 nM), displaying significant cellular activity against mutated BRAF and mutated NRAS cancer cell lines.

Reference:

1. M.Okaniwa , et al., Discovery of a Selective Kinase Inhibitor
(TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and
Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives,
J. Med. Chem., 2013, 56 (16), pp 6478–6494.

APIM050243: TAK-632

CAS No.: 1228591-30-7.
Molecular Formula: C₂₇H₁₈F₄N₄O₃S.
Molecular Weight: 554.5.
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: HPLC-MS, ¹HNMR.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.