Pseudouridine / 5-ribosyluracil Rabbit mAb
$148.00 – $548.00
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| Catalog No. | A20988 |
|---|---|
| Product Name | Pseudouridine / 5-ribosyluracil Rabbit mAb |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Gene Name | Pseudouridine |
| Protein Name | Pseudouridine |
| Clone | ARC50719 |
| Clonality | Monoclonal |
| Source/Host | Rabbit |
| Reactivity | Species independent |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
Pseudouridine (Ψ) was among the first post-transcriptional modifications discovered and is overall one of the most abundant（1）. It is present in a wide range of cellular RNAs and is highly conserved across species. Ψ is derived from uridine (U) via base-specific isomerization catalyzed by Ψ synthases. The site-specific pseudouridylation goes through either snoRNA-dependent (requires H/ACA RNP) or -independent mechanism (requires pseudouridine synthase (PUS) family enzymes)（2）. It has an extra hydrogen-bond donor at its non-Watson-Crick edge. When incorporated into RNA, Ψ can alter RNA secondary structure by increasing base stacking, improving base pairing and rigidifying sugar-phosphate backbone5. The chemical and physical properties of RNA can be altered with the incorporation of Ψ, which could contribute to subsequent cellular functions.
