PBF-509 (TAMINADENANT)

Background Information:

PBF-509 (Taminadenant, NIR178), an oral immunotherapy agent, is a potent and selective A_2A (Adenosine 2A) receptor antagonist, binding to human A_2A receptor with a Ki value of 12 nM. It inhibits A_2AR expressed on T lymphocytes, thus abrogates the adenosine/ A_2AR-mediated
inhibition of T-lymphocytes and activates a T-cell-mediated immune
response against tumor cells, thereby reducing proliferation of
susceptible tumor cells. It is also reported as a potential
pro-dopaminergic drug for Parkinson’s disease (PD) management.

APIM050272: PBF-509 (TAMINADENANT)

CAS No.: 1337962-47-6.
Molecular Formula: C10H8BrN7.
Molecular Weight: 306.1.
Purity: 99.5% by HPLC.
QC: HPLC, 1H-NMR, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.