NVP-LDE225 DIPHOSPHATE SALT (ERISMODEGIB, SONIDEGIB)

Description

Background Information:

A potent, selective, and orally bioavailable Smoothened (Hedgehog
Signaling Pathway) antagonist, currently in clinical trials. Diphosphate
salt offers a much better bioavailability than free base (Ref. 1).

Reference:

1. Pan, S., et al, Discovery of NVP-LDE225, a Potent and Selective
Smoothened Antagonist, ACS Med. Chem. Lett., 2010, 1 (3), pp 130–134.
2. 0 equivalent phosphate is confirmed by a spot-on Quantitative
Elemental Analysis – the most rigorous standard, achieved ONLY by
Chemietek. This product is functionally equivalent to the very same
material from Novartis (The drug developer) per our clients.

APIM050353: NVP-LDE225 DIPHOSPHATE SALT (ERISMODEGIB, SONIDEGIB)

CAS No.: 1218778-77-8.
Molecular Formula: C₂₆H₂₆F₃N₃O₃ ? 2H₃PO_4.
Molecular Weight: 681.5.
Purity: 99.9% (HPLC at 214 and 254 nm).
QC: HPLC, ¹HNMR and Quantitative Elemental Analysis Report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

Additional information

Ship from Country	USA
Size	10 mg, 100 mg, 200 mg, 50 mg

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