Muromonab Biosimilar, Anti-human CD3 Monoclonal Antibody | C054P

Catalog No.	C054P
Product Name	Muromonab Biosimilar, Anti-human CD3 Monoclonal Antibody | C054P
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	cluster of differentiation 3, CD3D, CD3E, CD3G
Summary	Recombinant mouse IgG2a Monoclonal Antibody.
Source/Host	The anti-human CD3 monoclonal antibody muromonab biosimilar was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade muromonab biosimilar specifically binds to the human T cell receptor CD3.
Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by muromonab.
Form Of Antibody	0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin	< 1 EU per 1 mg of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The research grade muromonab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note	The research grade Muromonab biosimilar protein is for research use only(RUO). Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card.

Description

C054P: Muromonab Biosimilar, CD3 Monoclonal Antibody

Recombinant Humanized IgG2a Monoclonal Antibody.

Background

Muromonab Biosimilar uses the same protein sequences as the therapeutic antibody muromonab.

Muromonab is a monoclonal anti-CD3 antibody used as immunosuppressive therapy in kidney, heart, and liver transplant patients.

Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).

Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.

Please remember our product information: Muromonab Biosimilar, CD3 Monoclonal Antibody: C054P Syd Labs

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