MIK665 (S64315)

Background Information:

MIK665 (S-64315) is a clinical-stage, BH3-Groove binding Mcl-1
inhibitor, potently and selectively binding to the protein target with
Ki in picomolar range. Demonstrates in vitro and in vivo antitumor
efficacy in Mcl-1 dependent cancer models. Achieves superior activity
and enhanced solid tumor response when applied in combination with
taxane compounds (ref. 1).

Reference:

1. a. Verified by Chiral HPLC; b. Binding potency (IC50 = 0.7 nM) was
measured for its ability to displace BAK peptide from Mcl1-BAK complex.

APIM050285: MIK665 (S64315)

CAS No.: 1799631-75-6.
Molecular Formula: C47H44ClFN6O6S?H2O.
Molecular Weight: 893.4 (refer to the certificate of analysis, batch-specific).
Purity: 99.9-100% Chemically, Atropisomerically and Enantiomerically Pure by achiral and chiral HPLCs.
QC: Achiral and Chiral HPLCs, MS, NMR, and Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.