Catalog No.	CD4-HM146
Product Name	Human CD46 Protein (CD4-HM146)
Supplier Name	KACTUS Biosystems
Brand Name	KACTUS Biosystems
Synonyms	TLX; CD46; MCP; MIC10; AHUS2; TRA2.10
Species	Human
Source	HEK293
Accession	P15529-1
Product Tag	C-His
Biotinylated	no
Exact Sequence	Cys35-Asp343
Molecular Weight	The protein has a predicted MW of 35.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
Form	Lyophilized
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per μg by the LAL method.
Shipping	Shipped at ambient temperature.
Stability & Storage	'-20 to -80°C for 12 months as supplied from date of receipt.；-20 to -80°C for 3-6 months in unopened state after reconstitution.；2-8°C for 2-7 days after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Note	Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline	Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

CD4-HM146: Human CD46 Protein (CD4-HM146)

CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated ‘self-attack’.

Please remember our product information: Human CD46 Protein (CD4-HM146) catalog number: CD4-HM146 KACTUS Biosystems

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