GSK2636771

Catalog No.	APIM050167
Product Name	GSK2636771

Description

Background Information:

GSK2636771 is an orally bioavailable PI3K β isoform-selective inhibitor, currently in clinical trials.

Reference:

1. RA Rivero, et al, Identification of GSK2636771, a potent and
selective, orally bioavailable inhibitor of phosphatidylinositol
3-kinase-beta (PI3Kβ) for the treatment of PTEN deficient tumors. Cancer
Res. 2012, 72(8 Supplement), 2913.
2. RM Sanchez, et al., Synthesis and structure–activity relationships of
1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β
isoform selective phosphatidylinositol 3-kinase inhibitors. Bioorg. Med.
Chem. Lett. 2012, 22(9), 3198-3202.
3. n vivo Grade. Through recrystallization and de-coloring (on Activated
Carbon), the product GSK2636771 offered is a white powder, in sharp
contrast to the yellow one offered by many other vendors.

APIM050167: GSK2636771

CAS No.: 1372540-25-4.
Molecular Formula: C₂₂H₂₂F₃N₃O_3.
Molecular Weight: 433.4 (Refer to The Certificate of Analysis, batch-specific).
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: MS, ¹HNMR, HPLC.
Solubility: Soluble in DMSO, and water with 1 eq. of base.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

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