Cynomolgus AMIGO2 Protein (AMI-CM102)
$283.50 – $945.00
KACTUS Biosystems Cynomolgus AMIGO2 Protein (AMI-CM102) (catalog No. AMI-CM102) is expressed from HEK293 with His tag at the C-Terminus.It contains Val39-Thr397.
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| Catalog No. | AMI-CM102 |
|---|---|
| Product Name | Cynomolgus AMIGO2 Protein (AMI-CM102) |
| Supplier Name | KACTUS Biosystems |
| Brand Name | KACTUS Biosystems |
| Species | Cynomolgus |
| Source | HEK293 |
| Accession | G7PHN7 |
| Product Tag | C-His |
| Biotinylated | no |
| Exact Sequence | Val39-Thr397 |
| Molecular Weight | The protein has a predicted MW of 41.97 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per μg by the LAL method. |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | '-20 to -80°C for 12 months as supplied from date of receipt.；-20 to -80°C for 3-6 months in unopened state after reconstitution.；2-8°C for 2-7 days after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
AMI-CM102: Cynomolgus AMIGO2 Protein (AMI-CM102)
Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis.
Please remember our product information: Cynomolgus AMIGO2 Protein (AMI-CM102) catalog number: AMI-CM102 KACTUS Biosystems
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug, 500 ug |