BI 6727 (VOLASERTIB)
$120.00 – $1,260.00
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| Catalog No. | APIM050114 |
|---|---|
| Product Name | BI 6727 (VOLASERTIB) |
Description
Background Information:
BI6727 (Volasertib)is a highly potent, selective and ATP-competitive inhibitor of polo-like kinases 1 , 2 and 3 (PLK1, 2 and 3), with IC50s at 0.87, 5 and 56 nM, respectively.
Reference:
1. Rudolph, D., et al, BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity, Clin Cancer Res., May 1, 2009; 15 (9), 3094-3102.
2. K. Strebhardt, Nature Reviews Drug Discovery, 9, 643-660 (August 2010)* A product coming with an excellent quantitative elemental analysis, made for in vivo studies . In stock from Indianapolis. Ship within 1 day.
APIM050114: BI 6727 (VOLASERTIB)
CAS No.: 755038-65-4.
Molecular Formula: C34H50N8O3?0.5H2O.
Molecular Weight: 627.8.
Purity: 99% (HPLC at 214 and 254 nm), >99% optical purity (Chiral HPLC referenced to opposite enantiomer).
QC: HPLC-MS, 1HNMR and Quantitative Elemental Analysis.
Solubility: In DMSO, alcohols, water with 2 eq. of acid.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
