BI 6727 (VOLASERTIB)

BI 6727 (VOLASERTIB)

$120.00$1,260.00

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$120.00$1,260.00

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SKU: APIM050114
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Description

Background Information:

BI6727 (Volasertib)is a highly potent, selective and ATP-competitive inhibitor of polo-like kinases 1 , 2 and 3 (PLK1, 2 and 3), with IC50s at 0.87, 5 and 56 nM, respectively.

Reference:

1. Rudolph, D., et al, BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity, Clin Cancer Res., May 1, 2009; 15 (9), 3094-3102.
2. K. Strebhardt, Nature Reviews Drug Discovery, 9, 643-660 (August 2010)* A product coming with an excellent quantitative elemental analysis, made for in vivo studies . In stock from Indianapolis. Ship within 1 day.

APIM050114: BI 6727 (VOLASERTIB)

CAS No.: 755038-65-4.
Molecular Formula: C34H50N8O3?0.5H2O.
Molecular Weight: 627.8.
Purity: 99% (HPLC at 214 and 254 nm), >99% optical purity (Chiral HPLC referenced to opposite enantiomer).
QC: HPLC-MS, 1HNMR and Quantitative Elemental Analysis.
Solubility: In DMSO, alcohols, water with 2 eq. of acid.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

Additional information

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USA

Size

10 mg, 100 mg, 200 mg, 5 mg, 50 mg

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