Catalog No.	PA008012.m2cLA
Product Name	Anti-mouse CD370 / PD-L1 Bispecific Antibody (Clone:10B4/10F.9G2.1) | PA008012.m2cLA
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	CLC9A, Clec9a, DNGR-1, C-type lectin domain family 9 member A, Programmed Death Ligand 1, B7-H1, CD274, 10F.9G2
Clone	10B4, the same variable region sequences as the rat anti-mouse CD370 monoclonal antibody (clone number: 10B4). 10F.9G2.1, the same variable region sequences as the rat anti-mouse PD-L1 monoclonal antibody (clone number: 10F.9G2).
Isotype	mouse IgG2c, kappa.
Applications	immunohistochemistry (IHC), Flow Cytometry (FC), and various in vitro and in vivo functional assays.
Form Of Antibody	0.2 μM filtered solution of 1x PBS.
Endotoxin	Less than 1 EU/mg of protein as determined by LAL method.
Purity	>95% by SDS-PAGE under reducing conditions.
Shipping	The in vivo grade recombinant rat anti-mouse CD370 / PD-L1 bispecific antibodies are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 3 month from date of receipt, 2 to 8°C as supplied. 12 months from date of receipt, -20°C to -70°C as supplied.
Note	Recombinant anti-mouse CD370 / PD L1 bispecific antibodies share the variable region sequences with the rat anti-mouse CD370 antibody (clone number: 10B4) and the rat anti-mouse PD-L1 antibody (clone number: 10F.9G2). The recombinant mouse IgG2c LALAPG bispecific isotype control antibody available.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA008012.m2cLA: In Vivo Grade Recombinant Anti-mouse CD370 / PD-L1 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 10B4 / 10F.9G2.1)

The in vivo grade recombinant rat anti-mouse CD370 / PD-L1 bispecific antibody (mouse IgG2c LALAPG Kappa) was produced in mammalian cells.

Background

The rat anti-mouse CD370 (Clec9A or DNGR-1) monoclonal antibody 10B4 (rat IgG2a kappa) reacts with the mouse CD370 protein. CLEC9A (C-type lectin domain family 9 member A), a transmembrane glycoprotein with a single extracellular C-type lectin domain (CTLD), plays a role in the immune response. As an activation receptor, CLEC9A is expressed on myeloid lineage cells, helps process material from dead cells, recognizes filamentous actin when cell membranes are damaged, and helps present antigens to cytotoxic T cells. CLEC9A has an intracellular cytoplasmic tail with potential signaling motifs. CLEC9A is expressed on a subset of BDCA3+ dendritic cells and CD16- monocytes in humans, and is expressed on CD8+ conventional DCs and plasmacytoid DCs in mice.

The rat anti-mouse PD-L1 monoclonal antibody 10F.9G2 (rat IgG2b kappa) reacts with the mouse PD-L1 protein (programmed death ligand-1, B7-H1 or CD274), a member of the B7 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD-1 and anti-mouse PD-L1 antibodies which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The 10F.9G2 monoclonal antibody blocks the binding of the mouse PD-L1 protein to the mouse PD-1 protein.

It is under investigation how the recombinant anti-mouse CD370 / PD-L1 bispecific antibodies (10B4 / 10F.9G2) behave different from the individual monoclonal antibodies and their combination.

Our recombinant anti-mouse CD370 / PD-L1 bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse CD370 antibody (hybridoma clone name or number: 10B4) and the rat anti-mouse PD-L1 antibody (hybridoma clone name or number: 10F.9G2).

Recombinant anti-HEL / HEL Bispecific Isotype Control Antibodies:
Anti-HEL / HEL Mouse IgG1 Bispecific Isotype Control Antibody (HyHEL-10 / HEL D1.3.) | Ushelf
Anti-HEL / HEL Mouse IgG2a Bispecific Isotype Control Antibody (HyHEL-10 / HEL D1.3.) | Ushelf
Anti-HEL / HEL Mouse IgG2c-LALAPG Kappa Bispecific Isotype Control Antibody (HyHEL-10 / HEL D1.3.) | Ushelf
Syd Labs provides the following anti-mouse CD370 and PD-L1 monoclonal antibodies:
In vivo grade recombinant anti-mouse PD-L1 monoclonal antibodies (Clone 10F.9G2.1)
In vivo grade recombinant anti-mouse CD370 monoclonal antibodies (Clone 10B4)
Syd Labs provides the following anti-mouse CD370 / PD-L1 bispecific antibodies:
In vivo grade recombinant anti-mouse CD370 / PD-L1 bispecific antibodies (Clone 10B4 / 10F.9G2.1)

In Vivo Grade Recombinant Anti-mouse CD370 / PD-L1 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 10B4 / 10F.9G2.1) from: In Vivo Grade Recombinant Anti-mouse CD370 / PD-L1 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 10B4 / 10F.9G2.1): PA008012.m2cLA

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