Recombinant Anti-mouse CD28 Antibody PA007490.h1Fs Ushelf

Anti-mouse CD28 Antibody for Flow Cytometry | PA007490.h1Fs

Name: Anti-mouse CD28 Antibody for Flow Cytometry
Brand: Syd Labs
SKU: PA007490.h1Fs
Price: 30-60 USD
Availability: InStock
Rating: 5 (1 reviews)

$60.00 – $120.00

Recombinant Mouse IgG1 isotype controls and Recombinant Human IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.

Details & Specifications
References

Catalog No.	PA007490.h1Fs
Product Name	Recombinant Anti-mouse CD28 Monoclonal Antibody (Clone: PV-1), Human IgG1 Fc Silent Kappa
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	T-cell-specific surface glycoprotein CD28; TP44
Clone	PV-1.
Isotype	Human IgG1 kappa.
Source/Host	The anti-mouse CD28 monoclonal antibody (clone: PV-1) for Flow Cytometry was produced in mammalian cells.
Specificity/Sensitivity	The recombinant PV-1 antibody for Flow Cytometry specifically binds to mouse CD28.
Applications	Flow cytometry (FC), and Immunohistochemistry - Frozen (IHC-F).
Form Of Antibody	0.2 uM filtered solution, pH 7.4, containing 0.09% sodium azide.
Conjugate	Non-conjugated.
Purity	>95% by SDS-PAGE under reducing conditions.
Shipping	The Recombinant Anti-mouse CD28 Monoclonal Antibody (Clone: PV-1) for Flow Cytometry, Human IgG1 Fc Silent Kappa is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, 2 to 8°C as supplied. Do not freeze it.
Note	Recombinant Human IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007490.h1Fs: Recombinant Anti-mouse CD28 Monoclonal Antibody (Clone: PV-1) for Flow Cytometry, Human IgG1 Fc Silent Kappa

Recombinant Human IgG1 Monoclonal Antibody with Fc silent mutation.

References of Anti-Mouse CD28 Monoclonal Antibody (Clone: PV-1)

1. CRK proteins selectively regulate T cell migration into inflamed tissues
Huang Y, et al.J Clin Invest. 2015 Mar 2;125(3):1019-32. PMID: 25621495
“Effector T cell migration into inflamed sites greatly exacerbates tissue destruction and disease severity in inflammatory diseases, including graft-versus-host disease (GVHD). T cell migration into such sites depends heavily on regulated adhesion and migration, but the signaling pathways that coordinate these functions downstream of chemokine receptors are largely unknown….”

2. Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice
Such J, et al.Mucosal Immunol. 2015 May;8(3):505-15. PMID: 25227984
“Mitogen-activated protein kinase (MAPK) phosphatases are dual-specificity phosphatases (DUSPs) that dephosphorylate phosphothreonine and phosphotyrosine residues within MAPKs. DUSP6 preferentially dephosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1/2) rendering them inactive….”

3. CXCL13 antibody for the treatment of autoimmune disorders
Klimatcheva E, et al.BMC Immunol. 2015 Feb 12;16:6. PMID: 25879435
“Homeostatic B Cell-Attracting chemokine 1 (BCA-1) otherwise known as CXCL13 is constitutively expressed in secondary lymphoid organs by follicular dendritic cells (FDC) and macrophages. It is the only known ligand for the CXCR5 receptor, which is expressed on mature B cells, follicular helper T cells (Tfh), Th17 cells and regulatory T (Treg) cells….”

4. Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors
Pallandre JR, et al.Eur J Med Chem. 2015 Oct 20;103:163-74. PMID: 26352675
“The development of inhibitors blocking STAT3 transcriptional activity is a promising therapeutic approach against cancer and inflammatory diseases. In this context, the selectivity of inhibitors against the STAT1 transcription factor is crucial as STAT3 and STAT1 play opposite roles in the apoptosis of tumor cells and polarization of the immune response….”

5. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
Bertin S, et al.Nat Immunol. 2014 Nov;15(11):1055-1063. PMID: 25282159
“TRPV1 is a Ca(2+)-permeable channel studied mostly as a pain receptor in sensory neurons. However, its role in other cell types is poorly understood….”

For more technical references or data sheets regarding the Recombinant Anti-Mouse CD28 Monoclonal Antibody (Clone: PV-1) formats, please contact our scientific support team at message@sydlabs.com or explore options via Syd Labs.