Recombinant Anti-mouse CD24 Monoclonal Antibody (M1/69.16.11.HL), In Vivo PA007623.r2b Syd Labs
In Vivo Grade Recombinant Anti-mouse CD24 Monoclonal Antibody (Clone M169.16.11.HL), Rat IgG2b Kappa

Anti-Mouse CD24 Antibody (Clone:M1/69.16.11.HL) | PA007623.r2b

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Recombinant Anti-mouse CD24 Monoclonal Antibody (M1/69.16.11.HL), In Vivo PA007623.r2b Syd Labs

Anti-Mouse CD24 Antibody (Clone:M1/69.16.11.HL) | PA007623.r2b

$150.00 – $900.00

In stock

$150.00 – $900.00

Recombinant rat IgG2b isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.

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Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Catalog No. PA007623.r2b
Product Name In Vivo Grade Recombinant Anti-mouse CD24 Monoclonal Antibody (Clone: M1/69.16.11.HL), Rat IgG2b Kappa
Supplier Name Syd Labs, Inc.
Brand Name Syd Labs
Synonyms CD 24, CD24 molecule, CD24A, FLJ22950, FLJ43543, MGC75043
Clone M1/69.16.11.HL.
Isotype Rat IgG2b Kappa.
Source/Host The anti-mouse CD24 monoclonal antibody (clone: M1/69.16.11.HL) was produced in mammalian cells.
Specificity/Sensitivity The in vivo grade recombinant rat monoclonal antibody (clone: M1/69.16.11.HL) specifically binds to mouse CD24.
Applications ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD24 protein.
Form Of Antibody 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin < 1 EU per 1 mg of the protein by the LAL method.
Purity >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping The in vivo grade recombinant anti-mouse CD24 monoclonal antibody of clone M1/69.16.11.HL is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note Recombinant rat IgG2b isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007623.r2b: In Vivo Grade Recombinant Anti-mouse CD24 Monoclonal Antibody (Clone: M1/69.16.11.HL), Rat IgG2b Kappa

Recombinant Rat IgG2b Monoclonal Antibody.

References of Anti-Mouse CD24 Monoclonal Antibody (Clone: M1/69.16.11.HL)

1. CD24 is expressed on FoxP3+ regulatory T cells and regulates their function.
Chen Y, et al.Front Immunol. 2022 Apr 15;13:855181. doi: 10.3389/fimmu.2022.855181. PMID: 35559385
“CD24-deficient Treg cells exhibited more potent suppressive capacity in inhibiting the development of experimental autoimmune encephalomyelitis (EAE) in mice. A representative proliferation assay using Tconv cells from CD24-/-C57BL6 mice as responder, irradiated splenocytes from CD24-/-Rag1-/- mice as APC in the presence and absence of different concentrations of anti-CD24 mAb (M1/69.16.11.HL). In vivo transfer of CD24-deficient Tregs into EAE recipient mice delayed disease onset. FoxP3+ Treg cells from CD24 knockout mice produced higher levels of IL-10 in vivo. Suppressive function of Tregs was enhanced in CD24-deficient mice during EAE induction.”

2. CD24 expression on regulatory T cells is necessary for suppression of colitis.
Yang X, et al.J Immunol. 2015 Jun 1;194(11):5337-45. doi: 10.4049/jimmunol.1403079. PMID: 25934567
“Colitis-induced mice were adoptively transferred with Tregs treated ex vivo with anti-mouse CD24 (M1/69.16.11.HL) before in vivo assessment. Anti-mouse CD24 blockade impaired Treg suppressive function in vivo. In vivo colitis scores were higher in recipients of anti-mouse CD24-treated Tregs. CD24+ Tregs were essential for mucosal tolerance in the model. IL-10 production by Tregs was reduced post-anti-mouse CD24 exposure.”

For more technical references or data sheets regarding the Recombinant Anti-Mouse CD24 Monoclonal Antibody (Clone: M1/69.16.11.HL) formats, please contact our scientific support team at message@sydlabs.com.

In Vivo Grade Recombinant Anti-mouse CD24 Monoclonal Antibody (Clone: M1/69.16.11.HL), Rat IgG2b Kappa from: In Vivo Grade Recombinant Anti-mouse CD24 Monoclonal Antibody (Clone: M1/69.16.11.HL), Rat IgG2b Kappa: PA007623.r2b

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