Recombinant Anti-human CD56 Monoclonal Antibody (Clone: N901) PA007347.h1Fs Syd Labs

Anti-human CD56 Antibody for Flow Cytometry | PA007347.h1Fs

$60.00 – $120.00

Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.

Details & Specifications
References

Catalog No.	PA007347.h1Fs
Product Name	Recombinant Anti-human CD56 Monoclonal Antibody (Clone: N901), Human IgG1 Fc Silent Kappa
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	Neural cell adhesion molecule, NCAM, CD56, MSK39, neural cell adhesion molecule 1, NCAM1
Clone	N901.
Isotype	Mouse IgG1 kappa.
Source/Host	The recombinant anti-human CD56 monoclonal antibody (clone: N901) for Flow Cytometry was produced in mammalian cells.
Specificity/Sensitivity	The recombinant N901 antibody for Flow Cytometry specifically binds to the human CD56 protein.
Applications	Flow cytometry (FC), and Immunohistochemistry - Frozen (IHC-F).
Form Of Antibody	0.2 uM filtered solution, pH 7.4, containing 0.09% sodium azide.
Conjugate	Non-conjugated.
Endotoxin	Less than 1 EU/mg of protein as determined by LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The Recombinant Anti-human CD56 Monoclonal Antibody (Clone: N901) for Flow Cytometry is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, 2 to 8°C as supplied. Do not freeze it.
Note	Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007347.h1Fs: Recombinant Anti-human CD56 Monoclonal Antibody (Clone: N901) for Flow Cytometry, Mouse IgG1 kappa, In vivo Grade

The recombinant N901 antibody binds to the human CD56 protein, a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. CD56 is a marker of neural lineage commitment. CD56 expression is found in the hematopoietic system, natural killer cells, and other lymphoid cells, including gamma delta (γδ) Τ cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory.

References of Anti-Human CD56 Monoclonal Antibody (Clone: N901)

1. Reduced Immunosenescence of Peripheral Blood T Cells in Parkinson’s Disease with CMV Infection Background
Sofia A. Kustova, et al.Biomedicines. 2021 Dec 2;9(12):1819. doi: 10.3390/biomedicines9121819. PMID: 34944635
“Immunosenescence is a process of remodeling the immune system under the influence of chronic inflammation during aging. Parkinson’s disease (PD) is a common age-associated neurodegenerative disorder and is frequently accompanied by neuroinflammation. Thus, PD is characterized by reduced peripheral blood T cell immunosenescence, even against the background of CMV infection.”

2. Surface NKG2C Identifies Differentiated ??T-Cell Clones Expanded in Peripheral Blood
Elena I. Kovalenko, et al.Front Immunol. 2021 Feb 16;11:613882. doi: 10.3389/fimmu.2020.613882. PMID: 33664730
“T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In both CD56+ and CD56- subsets most of the NKG2C+ T cells had a phenotype of highly differentiated CD8+ TEMRA cells. Thus, NKG2C expression in highly differentiated CD56+ T cells was associated with the most expanded ?? T cell clones.”

3. Alterations in the CD56? and CD56+ T Cell Subsets during COVID-19
Sofya A. Kustova, et al.Int J Mol Sci. 2023 May 16;24(10):9047. doi: 10.3390/ijms24109047. PMID: 37240393
“This work aimed to analyze the activation and differentiation of both circulating NKT-like cells and CD56? T cells during COVID-19 among intensive care unit (ICU) patients, moderate severity (MS) patients, and convalescents. Severe COVID-19 was accompanied by a decrease in the proportion of CD8+ T cells, mainly due to the CD56? cell death, and a redistribution of the NKT-like cell subset composition with a predominance of more differentiated cytotoxic CD8+ T cells. Overall, our findings suggest an antiviral role of CD56+ T cells in COVID-19.”

4. HLA-DR Expression in Natural Killer Cells Marks Distinct Functional States, Depending on Cell Differentiation Stage
Sofya A. Kust, et al.Int J Mol Sci. 2024 Apr 23;25(9):4609. doi: 10.3390/ijms25094609. PMID: 38731828
“HLA-DR-positive NK cells, found in both healthy individuals and patients with different inflammatory diseases, are characterized as activated cells. In this study, we evaluated the functional features of HLA-DR-expressing NK cells at various stages of differentiation. We demonstrated that HLA-DR expression marks distinct functional states of NK cells depending on their differentiation stage.”

5. First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial
François Ghiringhelli, et al.Nat Med. 2023 Aug;29(8):2080-2089. doi: 10.1038/s41591-023-02497-z. PMID: 37563240
“Although patients with microsatellite instable metastatic colorectal cancer benefit from immune checkpoint blockade, chemotherapy with targeted therapies remains the only therapeutic option for microsatellite stable (MSS) tumors. The single-arm, phase 1b/2 MEDITREME trial evaluated the safety and efficacy of durvalumab plus tremelimumab combined with mFOLFOX6 chemotherapy in first line. The combination of durvalumab + tremelimumab with mFOLFOX6 was tolerable with promising clinical activity in MSS mCRC.”

For more technical references or data sheets regarding the Anti-Human CD56 Monoclonal Antibody (Clone: N901) formats, please contact our scientific support team at message@sydlabs.com.

Syd Labs provides the following recombinant anti-human CD56 monoclonal antibodies for flow cytometry:

Anti-human CD56 ( N901) for Flow Cytometry from: Anti-human CD56 Monoclonal Antibody (Clone: N901): PA007347.h1Fs Syd Labs

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Anti-human CD56 Antibody for Flow Cytometry | PA007347.h1Fs