Anti-Human CD25 (IL-2R alpha) Antibody (Clone:7G7B6) | PA007573.m2a
$150.00 – $900.00
Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
- Details & Specifications
- References
| Catalog No. | PA007573.m2a |
|---|---|
| Product Name | In Vivo Grade Recombinant Anti-human CD25 (IL-2R alpha) Monoclonal Antibody (Clone: 7G7B6), Mouse IgG2a Kappa |
| Data Sheet | 📄 Download Product Data Sheet (PDF) |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | IL-2R alpha, Ly-43, p55, Tac |
| Clone | 7G7B6. |
| Isotype | Mouse IgG2a Kappa. |
| Source/Host | The anti-human CD25 (IL-2R alpha) monoclonal antibody (clone: 7G7B6) was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade recombinant mouse monoclonal antibody (clone: 7G7B6) specifically binds to human CD25 (IL-2R alpha). |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD25 (IL-2R alpha) protein. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The in vivo grade recombinant anti-human CD25 (IL-2R alpha) monoclonal antibody of clone 7G7B6 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA007573.m2a:In Vivo Grade Recombinant Anti-human CD25 (IL-2R alpha) Monoclonal Antibody (Clone: 7G7B6), Mouse IgG2a Kappa
Recombinant mouse Igg2a Monoclonal Antibody.
References of Anti-Human CD25 (IL-2Rα) Monoclonal Antibody (Clone: 7G7B6)
1. Regulatory T cells control toxicity in a humanized model of IL-2 therapy.
Li Y, et al.Nat Commun. 2017 Nov 24;8(1):1762. doi: 10.1038/s41467-017-01570-9. PMID: 29176694
“Treg constitutively express CD25 that allows them to efficiently capture IL-2 in vivo and as such, Treg numbers are correlated with IL-2 availability. …Absolute cell counts of CD25+ cells within CD45+CD3+CD4+Foxp3+ Treg and CD45+CD3+CD4+Foxp3− effector T (Teff) cells. …An anti-CD25 mAb was able to efficiently deplete Treg in HIS mice (Supplementary Fig. 5a, b). …Two injections of 300 µg anti-CD25 or anti-CTLA-4 depleting mAbs were given at D0 and D4. a, c Percentages of body weight change after LDIL2 treatment and mAb depletion in HIS mice were measured daily (n = 5 per group). …Both anti-CD25 and anti-CTLA-4 treated LDIL2 mice showed a reduction in the percentage of splenic Foxp3+ Treg.”
For more technical references or data sheets regarding the Recombinant Anti-Human CD25 (IL-2Rα) Monoclonal Antibody (Clone: 7G7B6) formats, or related products from Syd Labs, please contact our scientific support team at message@sydlabs.com.
In Vivo Grade Recombinant Anti-human CD25 (IL-2R alpha) Monoclonal Antibody (Clone: 7G7B6), Mouse IgG2a Kappa from: In Vivo Grade Recombinant Anti-human CD25 (IL-2R alpha) Monoclonal Antibody (Clone: 7G7B6), Mouse IgG2a Kappa: PA007573.m2a
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