Androgen Receptor Rabbit mAb (A19611)
$148.00 – $548.00
Abclonal Androgen Receptor Rabbit mAb (Catalog Number: A19611) gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain.
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| Catalog No. | A19611 |
|---|---|
| Product Name | Androgen Receptor Rabbit mAb (A19611) |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA |
| Gene Name | AR |
| Protein Name | AR |
| Uniprot/Swissprot ID | P10275 |
| Gene ID | 367 |
| Clone | ARC0090 |
| Clonality | Monoclonal |
| Source/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugate | Unconjugated |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
A19611: Androgen Receptor Rabbit mAb
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy’s disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen Information about Androgen Receptor Rabbit mAb (A19611)
Immunogen：A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Androgen Receptor (P10275).
Sequence：MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAH
Gene ID：367
Swiss prot：P10275
Synonyms：KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; Androgen Receptor
Calculated MW：99kDa
Observed MW：110kDa
Images of Androgen Receptor Rabbit mAb (A19611)
Western blot analysis of lysates from mouse testis, using Androgen Receptor Rabbit mAb (A19611) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90s.
Immunohistochemistry analysis of Androgen Receptor in paraffin-embedded human prostate cancer using Androgen Receptor Rabbit mAb (A19611) at dilution of 1:500 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Confocal imaging of paraffin-embedded Human prostate cancer using Androgen Receptor Rabbit mAb (A19611, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Objective: 40x. Perform high pressure antigen retrieval with 0.01 M citrate buffer (pH 6.0) prior to IF staining.
Immunoprecipitation analysis of 600 μg extracts of Mouse testis cells using 3 μg Androgen Receptor antibody (A19611). Western blot was performed from the immunoprecipitate using Androgen Receptor antibody (A19611) at a dilution of 1:1000.
Please remember our product information: Androgen Receptor Rabbit mAb (Catalog Number: A19611) Abclonal
