ABflo® 488 Rabbit anti-Human CD117/c-Kit mAb (A22586)
$290.00 – $768.00
Abclonal ABflo® 488 Rabbit anti-Human CD117/c-Kit mAb (Catalog Number: A22586) encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit.
- Details & Specifications
- References
- More Offers
| Catalog No. | A22586 |
|---|---|
| Product Name | ABflo® 488 Rabbit anti-Human CD117/c-Kit mAb (A22586) |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | PBT; SCFR; C-Kit; CD117; MASTC |
| Gene Name | KIT |
| Protein Name | KIT |
| Uniprot/Swissprot ID | P10721 |
| Gene ID | 3815 |
| Clonality | Monoclonal |
| Source/Host | Rabbit |
| Reactivity | Human |
| Conjugate | ABflo® 488. Ex:491nm. Em:516nm. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
A22586: ABflo® 488 Rabbit anti-Human CD117/c-Kit mAb
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen Information about ABflo® 488 Rabbit anti-Human CD117/c-Kit mAb (A22586)
Immunogen：Recombinant fusion protein containing a sequence corresponding to amino acids 26-520 of human CD117/c-Kit (NP_000213.1).
Sequence：QPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHT
Gene ID：3815
Swiss prot：P10721
Synonyms：PBT; SCFR; C-Kit; CD117; MASTC
Calculated MW：110kDa
Observed MW：Refer to figures
Images of ABflo® 488 Rabbit anti-Human CD117/c-Kit mAb (A22586)
Flow cytometry:1X10^6 MCF7 cells (negative control, Left) and HEL cells (Right) were surface-stained with ABflo® 488 Rabbit anti-Human CD117/c-Kit mAb(A22586, 5 μl/Test, orange line) or ABflo® 488 Rabbit IgG isotype control (A22069, 5 μl/Test, blue line). Non-fluorescently stained cells were used as blank control (red line).
Flow cytometry:1X10^6 HEL cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069, 5 μl/Test, left) or ABflo® 488 Rabbit anti-Human CD117/c-Kit mAb(A22586, 5 μl/Test, right).
Please remember our product information: ABflo® 488 Rabbit anti-Human CD117/c-Kit mAb (Catalog Number: A22586) Abclonal
