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Description
Background Information:
TORIN 2 is an orally available, potent and selective ATP-competitive
inhibitor of mTOR (Mammalian Target of Rapamycin) kinase with an IC50 of
0.25 nM, a 800 fold selectivity over PI3K (IC50 = 200 nM) (ref. 1).
Reference:
1. Liu, Q., et al, Discovery of
9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(
1H)-one (Torin2) as a potent, selective, and orally available mammalian
target of rapamycin (mTOR) inhibitor for treatment of cancer. J Med
Chem. 2011, 54, 1473-1480.
2. Liu Q., et al. “Characterization of Torin2, an ATP-competitive
inhibitor of mTOR, ATM, and ATR.” Cancer Res. 73: 2574-2586 (2013).
APIM050249: TORIN 2
CAS No.: 1223001-51-1.
Molecular Formula: C24H15F3N4O.
Molecular Weight: 432.4.
Purity: 99.9% by HPLC at 214 and 254 nm.
QC: HPLC-MS, 1H-NMR, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
