REGORAFENIB

Background Information:

Regorafenib is an orally active multi-kinase inhibitor targeting
angiogenic (VEGFR, TIE-2), stromal (PDGFR-β) and oncogenic (RAF, RET and
c-KIT) receptor tyrosine kinases, with IC50s of 17, 40 and 69 nM for
c-KIT, VEGFR2, B-Raf, respectively.

Reference:

1. Wilhelm, SM., et al., Int J Cancer, 2011 Jul 1; 129(1): 245-55.*Regorafenib Monohydrate (C₂₁H₁₅ClF₄N₄O₃?H2O) is the clinically active formulation format.

APIM050234: REGORAFENIB

CAS No.: 755037-03-7.
Molecular Formula: C₂₁H₁₅ClF₄N₄O₃ ? H₂O.
Molecular Weight: 500.83.
Purity: >99.5% chemical purity (HPLC).
QC: ¹HNMR, HPLC and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.