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Mouse EREG Protein (ERE-MM201)

Mouse EREG Protein (ERE-MM201)

Mouse EREG Protein (ERE-MM201)

$243.00$810.00

In stock

$243.00$810.00

KACTUS Biosystems Mouse EREG Protein (ERE-MM201) (catalog No. ERE-MM201) is expressed from HEK293 with hFc tag at the N-Terminus.It contains Val56-Leu101.

SKU: ERE-MM201
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Catalog No. ERE-MM201
Product NameMouse EREG Protein (ERE-MM201)
Supplier Name KACTUS Biosystems
Brand Name KACTUS Biosystems
Synonyms Proepiregulin; EPR; Epiregulin; EREG; ER
Species Mouse
Source HEK293
Accession Q61521
Product Tag N-hFc
Biotinylated no
Exact Sequence Val56-Leu101
Molecular Weight The protein has a predicted MW of 32.7 kDa. Due to glycosylation, the protein migrates to 37-40 kDa based on Tris-Bis PAGE result.
Form Lyophilized
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per μg by the LAL method.
Shipping Shipped at ambient temperature.
Stability & Storage '-20 to -80°C for 12 months as supplied from date of receipt.;-20 to -80°C for 3-6 months in unopened state after reconstitution.;2-8°C for 2-7 days after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Note Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

ERE-MM201: Mouse EREG Protein (ERE-MM201)

Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.

Please remember our product information: Mouse EREG Protein (ERE-MM201) catalog number: ERE-MM201 KACTUS Biosystems

Additional information

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USA

Size

100 ug, 500 ug

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