Human LRP-6 Protein (LRP-HM306)
$216.00 – $720.00
KACTUS Biosystems Human LRP-6 Protein (LRP-HM306) (catalog No. LRP-HM306) is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Ala20-Pro630.
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| Catalog No. | LRP-HM306 |
|---|---|
| Product Name | Human LRP-6 Protein (LRP-HM306) |
| Supplier Name | KACTUS Biosystems |
| Brand Name | KACTUS Biosystems |
| Synonyms | LRP-6; DCAD2; FLJ90062; FLJ90421 |
| Species | Human |
| Source | HEK293 |
| Accession | O75581-1 |
| Product Tag | C-mFc |
| Biotinylated | no |
| Exact Sequence | Ala20-Pro630 |
| Molecular Weight | The protein has a predicted MW of 95.3 kDa. Due to glycosylation, the protein migrates to 110-115 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Purity | > 90% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1EU per μg by the LAL method. |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
LRP-HM306: Human LRP-6 Protein (LRP-HM306)
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte activation, detachment, and transition to myofibroblasts in vivo in response to kidney injury, resulting in attenuated fibrogenesis, capillary rarefaction, and inflammation.LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin.
Please remember our product information: Human LRP-6 Protein (LRP-HM306) catalog number: LRP-HM306 KACTUS Biosystems