Human EREG Protein (ERE-HM201)
$283.50 – $945.00
KACTUS Biosystems Human EREG Protein (ERE-HM201) (catalog No. ERE-HM201) is expressed from HEK293 with hFc tag at the N-Terminus.It contains Val63-Leu108.
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| Catalog No. | ERE-HM201 |
|---|---|
| Product Name | Human EREG Protein (ERE-HM201) |
| Supplier Name | KACTUS Biosystems |
| Brand Name | KACTUS Biosystems |
| Synonyms | Proepiregulin; EPR; Epiregulin; EREG; ER |
| Species | Human |
| Source | HEK293 |
| Accession | O14944 |
| Product Tag | N-hFc |
| Biotinylated | no |
| Exact Sequence | Val63-Leu108 |
| Molecular Weight | The protein has a predicted MW of 32.6 kDa. Due to glycosylation, the protein migrates to 37-42 kDa based on Tris-Bis PAGE result. |
| Form | Liquid |
| Formulation | Supplied as 0.22μm filtered solution in PBS (pH 7.4). |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per μg by the LAL method. |
| Shipping | Shipped with dry ice. |
| Stability & Storage | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
ERE-HM201: Human EREG Protein (ERE-HM201)
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.
Please remember our product information: Human EREG Protein (ERE-HM201) catalog number: ERE-HM201 KACTUS Biosystems
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug, 500 ug |