GSK1120212 (TRAMETINIB)

Background Information:

GSK1120212 is a potent, highly selective and orally active inhibitor of MEK 1/2 inhibitor in clinical trial.

Reference:

1. Gilmartin AG, Bleam MR, Groy A, Moss KG, et al., GSK1120212
(JTP-74057) is an inhibitor of MEK activity and activation with
favorable pharmacokinetic properties for sustained in vivo pathway
inhibition, Clin Cancer Res. 2011 Jan 18. [Epub ahead of print].

APIM050162: GSK1120212 (TRAMETINIB)

CAS No.: 871700-17-3.
Molecular Formula: C₂₆H₂₃FIN₅O_4.
Molecular Weight: 615.39.
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: MS, ¹HNMR, HPLC, and quantitative elemental analysis report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.