BiP/GRP78 Rabbit mAb

Catalog No.	A23453
Product Name	BiP/GRP78 Rabbit mAb
Supplier Name	ABclonal, Inc.
Brand Name	Abclonal
Synonyms	BIP; GRP78; HEL-S-89n
Gene Name	HSPA5
Protein Name	HSPA5
Uniprot/Swissprot ID	P11021
Entrez GeneID	3309
Clone	ARC54734
Clonality	Monoclonal
Source/Host	Rabbit
Applications	WB, IHC-P
Reactivity	Human, Mouse, Rat
Conjugate	Unconjugated
Note	Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline	Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers.

Additional information

Ship from Country	USA
Size	20 ul, 100 ul, 200 ul, 50 ul

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