Biotinylated Human Notch 2 Protein (NOT-HM402B)
$135.00 – $450.00
KACTUS Biosystems Biotinylated Human Notch 2 Protein (NOT-HM402B) (catalog No. NOT-HM402B) is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Leu26-Gln530.
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| Catalog No. | NOT-HM402B |
|---|---|
| Product Name | Biotinylated Human Notch 2 Protein (NOT-HM402B) |
| Supplier Name | KACTUS Biosystems |
| Brand Name | KACTUS Biosystems |
| Synonyms | AGS2; Notch-2; NOTCH2; N2ECD; HJCYS; N2 |
| Species | Human |
| Source | HEK293 |
| Accession | Q04721 |
| Product Tag | C-His-Avi |
| Biotinylated | yes |
| Exact Sequence | Leu26-Gln530 |
| Molecular Weight | The protein has a predicted MW of 57 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per μg by the LAL method. |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
NOT-HM402B: Biotinylated Human Notch 2 Protein (NOT-HM402B)
Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Please remember our product information: Biotinylated Human Notch 2 Protein (NOT-HM402B) catalog number: NOT-HM402B KACTUS Biosystems