ADU-S100
$195.00 – $1,150.00
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| Catalog No. | APIM050006 |
|---|---|
| Product Name | ADU-S100 |
Description
Background Information:
ADU-S100 (MIW815) is a synthetic cyclic dinucleotide (CDN) agonist (activator) of Stimulator of Interferon Genes (STING), a receptor crucial to activate the innate (endogenous) immune system. ADU-S100 (MIW815) activates all known human and mouse STINGs, and effectively induces the expression of cytokines and chemokines, leading to a robust and durable antigen-specific T-cell mediated immune response against cancer cells (ref. 1).
Reference:
1. Corrales L et al., 2015. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11(7):1018-30.
*Water soluble (>73.5mg/ml, >100 mM). 1.0 mg in 1.0 ml water = 1.36 mM.
APIM050006: ADU-S100 (MIW815)
CAS No.: 1638750-95-4 (Sodium Salt), 1638241-89-0 (Free Acid)
Molecular Formula: C20H22N10O10P2S2?2Na
Molecular Weight: 734.5
Purity: >99.5% by HPLC (at 214 nm).
QC: HPLC, MS, 1H-, 31P-NMRs,
Solubility: Water (>36.7mg/ml, >50 mM).
Storage: refer to Certificate of Analysis.
