ABflo® 647 Rabbit anti-Human CD146 mAb (A22521)

ABflo® 647 Rabbit anti-Human CD146 mAb (A22521)

$218.00$568.00

In stock

$218.00$568.00

Abclonal ABflo® 647 Rabbit anti-Human CD146 mAb (Catalog Number: A22521) Melanoma cell adhesion molecule (MCAM, MUC18, CD146) is an immunoglobulin superfamily member originally described as a cell surface adhesion protein and marker of the progression and metastasis of melanoma .

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Catalog No. A22521
Product NameABflo® 647 Rabbit anti-Human CD146 mAb (A22521)
Supplier Name ABclonal, Inc.
Brand Name Abclonal
Synonyms CD146; MUC18; HEMCAM; METCAM; MelCAM
Gene Name MCAM
Protein Name MCAM
Uniprot/Swissprot ID P43121
Entrez GeneID 4162
Clonality Monoclonal
Source/Host Rabbit
Applications FC
Reactivity Human
Conjugate ABflo® 647. Ex:656nm. Em:670nm.
Note Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

A22521: ABflo® 647 Rabbit anti-Human CD146 mAb

Melanoma cell adhesion molecule (MCAM, MUC18, CD146) is an immunoglobulin superfamily member originally described as a cell surface adhesion protein and marker of the progression and metastasis of melanoma . Expression of MCAM protein is seen in vascular endothelial cells, activated T lymphocytes, smooth muscle, and bone marrow stromal cells. Research studies demonstrate increased MCAM expression in endothelial cells from angiogenesis-related disorders, including inflammatory bowel disease, Crohn’s disease, rheumatoid arthritis, tumors, and chronic renal failure . MCAM-expressing human mesenchymal stromal cells (hMSC) in the hematopoietic microenvironment are responsible for maintaining the self-renewal of hematopoietic stem and progenitor cells (HSPC) through direct contact between hMSC and HSPC. Related studies suggest that activation of the Notch signaling pathway may also, in part, play a role in HSPC maintenance . Additional research indicates that MCAM may play a role in multiple sclerosis, an autoimmune inflammatory disease that affects central nervous system neurons. Endothelial MCAM within the blood-brain barrier act as adhesion receptors that permit lymphocytes to transmigrate across the barrier and produce the inflammatory lesions that characterize the disorder .

Immunogen Information about ABflo® 647 Rabbit anti-Human CD146 mAb (A22521)

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-559 of human CD146 (NP_006491.2).
Sequence:VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRG
Gene ID:4162
Swiss prot:P43121
Synonyms:CD146; MUC18; HEMCAM; METCAM; MelCAM
Calculated MW:57kDa/72kDa
Observed MW:Refer to figures

Images of ABflo® 647 Rabbit anti-Human CD146 mAb (A22521)

Flow cytometry:1X10^6 MCF7 cells (negative control, left) and HUVEC cells (right) were surface-stained with ABflo® 647 Rabbit anti-Human CD146 mAb(A22521, 5 μl/Test, orange line) or ABflo® 647 Rabbit IgG isotype control (A22070, 5 μl/Test, blue line). Non-fluorescently stained cells were used as blank control (red line).

Flow cytometry:1X10^6 HUVEC cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070, 5 μl/Test, left) or ABflo® 647 Rabbit anti-Human CD146 mAb(A22521, 5 μl/Test, right).

Please remember our product information: ABflo® 647 Rabbit anti-Human CD146 mAb (Catalog Number: A22521) Abclonal

Additional information

Ship from Country

USA

Size

100 μg, 25 μg, 50 μg

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