ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb (A22304)
$290.00 – $768.00
Abclonal ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb (Catalog Number: A22304) encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells.
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| Catalog No. | A22304 |
|---|---|
| Product Name | ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb (A22304) |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1 |
| Gene Name | CD274 |
| Protein Name | CD274 |
| Uniprot/Swissprot ID | Q9NZQ7 |
| Entrez GeneID | 29126 |
| Clonality | Monoclonal |
| Source/Host | Rabbit |
| Applications | FC |
| Reactivity | Human |
| Conjugate | ABflo® 488. Ex:491nm. Em:516nm. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
A22304: ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Immunogen Information about ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb (A22304)
Immunogen：Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human PD-L1/CD274 (Q9NZQ7)
Sequence： MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
Gene ID：29126
Swiss prot：Q9NZQ7
Synonyms：B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1
Calculated MW：33kDa
Observed MW：Refer to figures
Images of ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb (A22304)
Flow cytometry: 1X10^6 K-562 cells (negative control, left) and MDA-MB-231 cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb (A22304, 2 μg/mL, orange line) or ABflo® 488 Rabbit IgG isotype control (A22069, 2 μg/mL, blue line). Non-fluorescently stained cells was used as blank control (red line).
Flow cytometry: 1X10^6 MDA-MB-231 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069, 5 μl/Test, left) or ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb (A22304, 5 μl/Test, right).
Please remember our product information: ABflo® 488 Rabbit anti-Human PD-L1/CD274 mAb (Catalog Number: A22304) Abclonal
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 μg, 25 μg, 50 μg |