Catalog No.	C070P
Product Name	Zolbetuximab Biosimilar, Claudin 18.2 Antibody | C070P
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	Claudiximab, IMAB362, IMAB-362
Summary	Recombinant Humanized IgG1 Monoclonal Antibody.
Isotype	Human IgG1 kappa.
Source/Host	The anti-human Claudin 18.2 monoclonal antibody zolbetuximab biosimilar was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade zolbetuximab biosimilar specifically binds to the human Claudin 18.2 protein.
Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by zolbetuximab (IMAB-362).
Form Of Antibody	0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin	< 1 EU per 1 mg of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The research grade zolbetuximab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note	The research grade Zolbetuximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card.

Description

C070P: Zolbetuximab Biosimilar, Claudin 18.2 Monoclonal Antibody
Recombinant Humanized IgG1 Monoclonal Antibody.

Background

What is zolbetuximab biosimilar research grade? Zolbetuximab is a humanized monoclonal antibody directed against the human protein Claudin 18.2 (the isoform 2 of Claudin), and potentially used for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. Zolbetuximab is an Fc-engineered, humanized, monoclonal antibody (IgG1κ isotype). Zolbetuximab biosimilar uses the same protein sequences as the potential therapeutic antibody zolbetuximab .

Claudin-18 in humans is a protein encoded by the CLDN18 gene. The CLDN18 protein belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

Syd Labs also provides the following research grade anti-Claudin 18.2 antibody biosimilar proteins

Zolbetuximab Biosimilar from: Zolbetuximab Biosimilar, Claudin 18.2 Monoclonal Antibody: C070P Syd Labs

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